Therapy of the metabolic disorders HPU/KPU

Some minor metabolic disorders that can have a big effect and are often overlooked for that very cause are haemopyrrollactamuria (HPU) and kryptopyrroluria (KPU).

These often start with non-specific symptoms that many of our patients describe as follows:
“I feel constantly tired, I hardly have enough strength to get through the day, I easily feel overwhelmed. I often find it hard to concentrate. Sometimes I feel dizzy for no obvious reason. But these problems aren’t permanent, sometimes they are not as strong and I feel better and then for no reason they get worse again. I can’t link them to food, lack of sleep or exposure to anything in particular, they just come and go. The usual lab test results don’t show up any obvious problems, although my cholesterol is a bit high. My friends and family tell me that this is really all in my mind. They suggest relaxation or physical exercise, but this doesn’t often help or I can’t get motivated to do it at all”.

For children, they often also have problems at school because they lack focus and concentration. Sometimes diagnoses like ADHD are made. The child is often described as “lazy”, dreamy, untidy, unreliable, and forgetful. In many cases these children are intelligent but can’t apply their ability to perform to their potential in school.

All age groups can be affected. Adult patients often have many subsequent symptoms that develop through not treating the underlying condition early enough. Often one of these later symptoms is the reason they start to look for therapeutic help.

The list of subsequent conditions is long: unfulfilled desire to conceive, intestinal problems, low blood pressure, iron deficit, problems with the thyroid gland, Hashimoto syndrome, histamine intolerance and other allergic reactions, sensitivity to chemicals, electro-sensitivity, chronic fatigue syndrome and burn-out, sleep problems, depression, mood swings, gallbladder troubles, menstrual disorders, problems in the urinary tract, arthrosis, arthritis, osteoporosis, fibromyalgia and migraines, to name a few.

These people are often surprised and sceptical when they hear that their problems are caused by a “harmless metabolic disorder” which is currently not currently widely known through the medical community.

Even though as a therapist I knew about this disorder, I was very sceptical to start with. It was only after diagnosing and treating many HPU/KPU patients and gaining a lot of experience along the way, that I changed my mind. Today, HPU/KPU diagnosis is a very important tool for me to find the source of my patients’ illnesses.

Was ist nun HPU/KPU?

HPU (haemopyrrollactamuria) or KPU (kryptopyrroluria) are two very similar metabolic disorders. They are both diagnosed through the presence of specific substances in the urine.

Both disorders have in common that haeme, the red “colour” of blood, which is later used to build for example haemoglobin, isn’t always perfectly produced, so that the incorrectly produced haeme has to be excreted. One of the problems brought about by this is a lower than average supply of oxygen to body.

For excretion of the incorrectly built haem-molecules, they are bound to substances like the group of B-vitamins, zinc, manganese and chrome. The loss of these substances is so large that even a well balanced diet cannot maintain the required supply. This can lead to a disturbed function of the mitochondria as well as a weakened detoxification system and excretion function among other things.

HPU/KPU was first discovered in psychiatric research and can lead to a number of psychological problems like depression, which makes this disorder extremely hard to diagnose by its symptoms alone.

Woran erkenne ich, dass ich HPU/KPU habe?

The symptoms can be extremely diverse. If the description of the symptoms in the text above resonates with you, even if only partially, or if you have undiagnosed or untreatable physical or psychological conditions, a urine test can quickly give a definitive answer as to whether you have one of these conditions or not.

To do this, either the morning urine is used or a collection of all your urine from a 24 hour period. The lab results will show definitively how much of these substances are excreted within the urine.

Feel free to talk to us about what kind of test could be right for you. The cost of these urine tests depends on which kind of test is necessary and is between 35€ and 70€ per person.

Was kann man gegen HPU/KPU therapeutisch machen?

Following a positive urine test, further lab tests may be necessary to assess subsequent pathology of the disorder, depending on the symptoms exhibited. Since these can vary greatly, there is no standard treatment plan.

The first aim in all cases is to restore proper mitochondrial function. Different therapy elements can be added to that, depending on the problems the patient has.

An important part of the treatment is re-supplying the body with the substances it consumes to deal with the condition. However, too high a dose of some of these substances can lead to the symptoms worsening. We do not subscribe to the view that “dietary supplements can’t hurt” because we have experience that would suggest the contrary. Please always consult a medical professional before trying anything.

I usually recommend a detailed laboratory test to see the level of supply the patient has currently. This can be easily done with a small blood sample. From there we can put together a specific individual treatment plan. Some important parameters can also be gained from a small drop of blood from the tip of the finger for children who are afraid of needles.

If you have any questions about HPU and/or KPU or the treatments we offer please feel free to contact me.